抄録
Thirty two patients with endogenous depressino were treated with cloxazolam, one of the benzodiazepine derivatives recently synthesized in Japan, in an open clinical trial. Twenty eight patients continued to receive previously prescribed antidepressants concomitantly with cloxazolam, and four patients cloxazolam alone.Fifty percent of all the patients showed clinical improvement. Therapeutic efficacy of the drug was significantly lower in bipolar type than in unipolar type (p<0.01).In most patients, cloxazolam was particularly effective for the improvement of anxiety. In some patients, the improvement of depressive mood or psychomotor retardation was accompanied with that of anxiety.In 12 patients cloxazolam was compared with other minor tranquilizers as diazepam, oxazolam etc., in cross over method.In 7 patients cloxazolam had better therapeutic efficacy, and in 5 patients depressive symptoms remained unchanged.Main side effect was drowsiness, which was observed in 8 patients.
