抄録
Influence of sterss on IgE antibody formation was studied regarding primary responses in mice. To elucidate part of the mechanism of inhibitory influence of stress on immuneresponse, effects of pretreatment with steroid agents administration prior to stressing were also investigated.The relationship between serum IgE levels and three psychological tests i.e. Cornell Medical Index (CMI), Comprehensive Asthma Inventory (CAI) and Self-rating Depression Scale (SDS), were studied in the patients with bronchial asthma.The following results were obtained.1. IgE antibody production in primary response was explicitly inhibited by stressing prior to antigen sensitization. However, stressing after antigen sensitization had no effect in IgE antibody production.2. In secondary response, no influence of stressing prior to secondary immunization was detected. Stressing prior to primary immunization, however, inhibited secondary response markedly.3. There was a dose-response correlation between the amount of stressing prior to primary immunization and IgE antibody production.4. Antibody production was moderately inhibited by administration of hydrocortisone, prednisolone and dexamethasone prior to primary immunization.5. There were no differences in the serum IgE levels among the profile of CMI, CAI and SDS.
