抄録
A study was made with regard to influences of psychological, autonomic nervous and character factors up on the results of a double-blind study of Y-12141,an anti-allergic drug. The subjects consisted of 239 patients (above age 13 years) with moderate or severe perennial allergic rhinitis and the method used was a questionnaire which was prepared by Dr. Okuda, one of the authors. The result, showed that the personality factors significantly affected the drop-outs and global assessment of efficacy, whereas the autonomic nervous factors were significantly correlated to the improvement in nasal discharge and to the combined use of other anti-allergic drugs. However, it seemed that these factors might not exert marked influences upon the rate of drug intake, effect of placebo, objective findings and improvement of subjective symptoms. Furthermore psychological factors were significantly correlated to the sex and type of disease, while the autonomic nervous factors to the sex, age onset, severity and types of disease.
