抄録
Denture stomatitis is a term used to describe certain pathologic changes found in the oral mucosa of denture-bearing tissues. With regard to this etiology, infection with Candida species is one of the factors which may be implicated in the initiation of denture stomatitis. Because Candida species have been cultured more frequently and in larger numbers in denture stomatitis than in controls. C. albicans is the most common species. On the other hand, a carbohydrates is one of factors that promote Candida-induced inflammation. Therefore, we examined whether carbohydrates affected initiation and/or aggravation of Candida-induced stomatitis.
Male Wistar rats were used in this experimental study, and C. albicans A 4-105 and C. albicans BIA-40 were used for inoculation. The animals were fitted with acrylic palatal plates inoculated with C. albicans A or B, and fed on normal or carbohydrate-rich diets. At 1 or 2 weeks afterinoculation, the animals were killed and their palatal mucosae were examined culturally and histologically. As a result, we have found a tendency for intraepithelial penetration of C. albicans A to be promoted by carbohydrates, but initiation and aggravation of C. albicans A-induced inflammation are affected to a lesser degree. With respect to C. albicans B, intraepithelial penetration and occurrence of inflammation are scarcely influenced by carbohydrates.
