抄録
A case of primary diffuse tracheobronchial amyloidosis which is a rare variant of amyloidosis, is reported. A 51-year-old male whose occupation was a factory manager had cough and wheezing at night. Bronchoscopy revealed diffuse thickening and irregular bosselation at the wall of the lower part of the trachea and of the main bronchi of the both sides, especially at the cartilagous part. The orifice of the left upper lobe bronchus narrowed extremely owing to these changes. Microscopic examination of the tracheal fragments biopsied from the area of the carina showed diffuse depposition of amorphous mass which gave positive staining reactions for amyloid in the submucosa. Electron microscopic findings were those of “pen-collagen amyloidosis.” This patient had never been suffered from any long-standing suppurative or inflammatory diseases. His serum protein fractions were normal, and rectal biopsy did not yield positive staining reactions for amyloid. From these findings the case was diagnosed as primary diffuse tracheobronchial amyloidosis.
