抄録
The effect of oxygen inhalation on mixed venous and arterial oxygenation was studied by right cardiac catheterization in patients with respiratory failure due to chronic obstructive pulmonary disease. Data on the relationship between avPO2 and PaO2 in 50 patients while breathing air suggested control mechanism (s) minimizing the effect of aVPO2 approaching to zero. Cardiac output, arterial lactate concentration, PaO2 and PvO2 were measured before, and 1 hour after, breathing 100% oxygen in 23 patients. Marked rise in PvO2 and significant decrease in arterial lactate were observed after oxygen administration in more hypoxic (PaO2<60mmHg while breathing air) patients, while no significant difference was seen in PaO2 and cardiac output between more hypoxic and less hypoxic (PaO2≥60mmHg) patients. Theoretically increase in PvO2 after oxygen administration was mainly due to decrease in tissue oxygen consumption in more hypoxic patients.
These results suggest that oxygen administration is indicated to relieve tissue hypoxia in patients with PaO2 less than 60mmHg.
