抄録
An influence of blood hemoglobin concentration (Hb) on pulmonary diffusing capacity (DL) was studied.
Thirty-four anemic and nonanemic subjects who were selected for the present study were all considered as being free of any primary cardiopulmonary diseases, based on radiological examinations, ventilatory function tests, and their past history. In each of these subjects, DL, membrane diffusing capacity (DM), and pulmonary capillary blood volume (Vc) were measured according to the method of Roughton and Forster, and Hb by the standard hematologic technic In 7 cases of severe anemia were DL, DM, and Vc measured before and after the treatment of anemia.
The results obtained are summarized in the following:
1) There was a positive correlation between Hb and DL, i. e., the lower the Hb, the lower the DL. In a group of those 7 anemics in which DL was measured before and after the treatment, an average DL increased from 12.1 to 17.8ml/min/mmHg, as Hb rised from 7.0 to 11.8g/dl followingt he treatment.
2) The mean for DM and Vc was 66.0±35.5ml/min/mmHg and 57.0±24.3ml, respectively and there was no correlation between either DL or Vc and Hb. In the 7 anemics did Vc remain unchanged through pre- and post-treatment.
3) A positive linear correlation was observed between Hb and diffusing capacity of red cells (θ⋅Vc) in all cases including those 7 cases in which anemia was much corrected by the treatment.
Thus, rise and fall of Hb appeared closely associated with proportional increase and decrease in θ⋅Vc resulting in increase and decrease in DL.
