抄録
The influence of carcinostatic agents upon squamous cell carcinoma of extremities was studied in six cases cytologically and histologically. Out of them, 3 were thermal burn scar carcinoma. Mitomycin C (MMC) and Bleomycin (BLM) were used as carcinostatic agents. Three of four cases to whom MMC was administered underwent a local perfusion. The remaining two cases were given 15 mg of BLM intravenously three times weekly.
The cytological changes of cancer cells by carcinostatic agents were summarized as follows 1) vacuole formation in cytoplasm and nucleus 2) multinuclear cell 3) enlargement of cell and nucleus 4) disarrangement of nuclear chromatin pattern 5) diminution of staining intensity. The prominent destruction of carcinoma pearl and the diminution of cancer cells accompanying with nuclear pyknosis or karyorrhexis were histologically observed in cancerous lesion. Moreover, nuclear pyknosis and decrease of basal cells were found in the normal basal layer. In conclusion, these changes of cancer cells are a nonspecific degeneration which is influenced by carcinostatic agents, but occurrs very frequently in noadministered cases. The changes of cancer cells shows only retrogressive degeneration. So appearance of degenerated cells is in parallel with the effect of carcinostatic agents, that the pursuit of cell changes may be of great usefulness in defining the influence of carcinostatic agents.
