新生児腔脂膏に関する細胞学的研究, 特にSteroid代謝との関連について

抄録

Cytological studies on vaginal smears of the newborn with special reference to relations between steroid metabolism and cytological changes.
Fractionation was made of steroids in the urine of the new born; day to day determinations were performed of estriol and 17 OS in reference to cytological findings.
1) Predominantly abundant esteriol was determined on a day to day basis, revealing the highest amount 1-2 days after birth followed by a rapid decrease till no determination was made on the seventh postnatal day. On cytological vaginal smears there were observed the estrogen effect and a slight progesterone effect on the day of birth, a marked estrogen effect only a day after birth, and on estrogen effect five days after birth showing good correspondence with the results of determination.
2) In the fractination of 17 OS DHEA proved to be dominant. 17 OS showed no marked changes for five days after birth. It showed on increase five days after birth reaching a maximum on the seventh postnatal day. On cytological vaginal smears the androgen effect which was observed about seven days after birth showed good correspondence with the determined value of 17 OS. The development of the androgen effect at this stage seemed to be due to the disappearance of estrogen.
3) On cytological vaginal smears, it was assumed that seven days after birth the value of 17 OS showed an increase which was maintained till about 11 days after birth, followed by a decrease which lasted for same time after the 15 th postnatal day.
4) It was assumed that DHEA in 17 OS played an important role in the androgen effect.