日本臨床細胞学会雑誌
Online ISSN : 1882-7233
Print ISSN : 0387-1193
ISSN-L : 0387-1193
Paget病の剥離細胞診
特に悪性黒色腫との鑑別
山田 喬信田 重光日高 知昭佐藤 豊彦上井 良夫柴田 偉雄石垣 実弘室久 敏三郎岡本 一也土井 久平田中 昇池田 栄雄垣花 昌彦浦崎 政浩
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1978 年 17 巻 3 号 p. 301-309

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In the present paper, the cytodiagnostic findings of 9patients, having 7 mammary and 2 extramammary Pagetdiseases each, are discussed with emphasis on their cytologic features and mechanism of melanin pigmentationinto the cytoplasma of cancer cells. In the smear specimens collected by scraping or needle-aspiration, largecancer cell clusters occasionally mixed with benign epidermal cells, anisonucleosis, large typical Paget's cells withwide cytoplasma, melanin-pigmentation into the cytoplasma and occasionally presence of melanocytes werecharacteristic for the cytodiagnostic features of the presentdiseases.
It is proposed that melanin pigmentation into the cytoplasma of the cancer cells is presumably induced through thesame mechanism as that of epidermal cells reported.

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