過敏性肺臓炎の気管支洗浄液に出現する異型リンパ球の検討

抄録

In hypersensitivity pneumonitis (HP), bronchoalveolar lavage (BAL) sometime show atypical lymphocytes (AT). We compared lymphocytes from (5 patients) with BAL flui from small lymphocytic lymphoma and leukemia (LL from 6 patients). In a Giemsa-stained specimen, 500 lymphocytes per case were categorized as N (normal), A (smaller than a neutrophil, atypical nuclear shape), AS (A with abnormal chromatin), and AL (larger than a neutrophil, with atypia), then calculated the ratio of each category. AT accounted for 14 to 22%(A + AS, AL= 0%) in HP, but LL showed a high A+AS ratio (>51.7%) with AL (>0.2%). Thus, calculating the ratio of small AT is important to avoid misinterpretation of BAL samples when AT is observed.