Malignant tumors of the female urethra are reportedly uite rare. We report a case of clear-cell carcinoma in a 42-year-old woman treated by urethrectomy. The tumor was located mainly in the muscular layer and tubulopapillary proliferation was microscopically evident. Hobnail and clear cells were observed histologically in some areas, with similar findings seen in voided urine. Immunohistochemical stains for prostate-specific acid phosphatase and prostatespecific antigen were negative. Tumor cells in this case were similar to those of ovarial clear-cell caricnoma. Further studies are needed, however, to establish the origin ofurethral clear-cell carcinoma.
We report a case of peritoneal malignant mesothelioma in a 66-year-old man, comparing ascites aspiration cytology and the tumor imprint at autopsy. Cytology showed papillary clusters of epithelioid cells with hyperchromatic nuclei and prominent nucleoli. Autopsy showed mainly atypical spindle cells intermingled with epithelioid cell islands. Findings of imprint cytology reflect the histological structure making it useful in differentiating mesothelioma from adenocarcinoma.
A 57-year-old woman with an adenomatous goiter of the thyroid gland for 3.5 years, suffered rapid enlargement of the thyroid gland. Aspiration cytology showed only a few tumor cells having bizarre nuclei and abundant cytoplasm. Thyroidectomy and subsequent chemotherapy were ineffective, and the patient died within 4 months after the thyroidectomy. Thyroid gland histology showed an undifferentiated carcinoma composed of pleomorphic tumor cells with a few osteoclast-like giant cells. The present case shows that a few tumor cells with bizarre nuclei in cytology during the course of an adenomatous goiter of the thyroid gland indicates development of an undifferentiated carcinoma.
In hypersensitivity pneumonitis (HP), bronchoalveolar lavage (BAL) sometime show atypical lymphocytes (AT). We compared lymphocytes from (5 patients) with BAL flui from small lymphocytic lymphoma and leukemia (LL from 6 patients). In a Giemsa-stained specimen, 500 lymphocytes per case were categorized as N (normal), A (smaller than a neutrophil, atypical nuclear shape), AS (A with abnormal chromatin), and AL (larger than a neutrophil, with atypia), then calculated the ratio of each category. AT accounted for 14 to 22%(A + AS, AL= 0%) in HP, but LL showed a high A+AS ratio (>51.7%) with AL (>0.2%). Thus, calculating the ratio of small AT is important to avoid misinterpretation of BAL samples when AT is observed.
A 31-year-old woman presented with a solid 4×4 cm right breast tumor on echography, which further showed an irregular border and a heterogenous internal echo. Aspiration cytology showed clusters of atypical small cells indicating invasive ductal cancer, so modified radical mastectomy was done. Stamp cytology showed atypical lymphoid cells without clusters, indicating malignant lymphoma. The histological diagnosis was diffuse mixed B-cell malignant lymphoma.
A rare case of subependymal giant cell astrocytoma without tuberous sclerosis is documented. A tumor was detected in the anterior horn of the left lateral ventricle of a 12-year-old boy. Both imprint smear cytology and histology revealed the presence of large epithelioid cells with eccentric nuclei and thick eosinophilic cytoplasm. Most epithelioid cells were strongly positive for S-100, vimentin, and neuron specific enolase on immunohistochemistry, and a few cells showed weak a positivity for glial fibrillary acidic protein and neurofilament. These large epithelioid cells were considered to represent an intermediate lineage between astrocytes and neurons.