This paper describes a rare case of intussusception in a three-day-old female with melena and bilous vomiting. The abdomen was slightly distended. A mass was palpable in the left abdomen. The abdominal plain film demonstrated dilatated loops of bowel at the center of the abdomen. The barium enema examination revealed a filling defect ranging from the descending colon to the rectum. No barium passed into the transverse colon. The operative finding presented an ileo-colic intussusception. An attempt of manual reduction resulted in perforation of the transverse and sigmoid colon. At last a right hemicolectomy and an end-to-end anastomosis were performed. A tube-sigmoidostomy was done. The pathological examination of the surgical specimen revealed a 2 cm saccular duplication of the terminal ileum. On the 1st postoperative day, the infant became septic, but she recovered by the exchange transfusion and the other intensive medical therapy. The following course was uneventful.