抄録
In 40 cases of full term pregnancey cesarean section performed before and during onset of labor. The amniotic fluid and blood samples from the uterine artery (U. A), uterine vein (U. V) and the peripheral vein (P. V) were collected and the changes of FPA, FPB β 15-42, HMW-kg, LMW-kg, glandular kallikrein and kinin were studied.
The levels of FPA in UV increased significantly during onset of labor as compared to the increase in UA and PV and although the UV level of FPB β 15-42 also showed the same as that of FPA pattern of increase during labor but the increase was not so sharp. Levels of HMW- and LMW-kg gradually decreased during onset of labor but no significant differences among UV, UA and PV were found, Level of kinin in PV increased significantly during labor but remained unchanged in UV. In the amniotic fluid, the levels of FPA, FPB β 15-42, and HMW-kg increased gradually while that of kinin increased significantly and decreases of glandular kallikrein, LMW-kg and kininase II were seen during labor.
These findings suggested that with the increased consumption of HMW- and LMW-kg and kinin during labor, the uteroplacental circulation exhibited a state of hypercoagulability with secondary hyperactivity of plasmin resulting in the increase in vascular permeability to the amniotic fluid and increased production of kinin.
