抄録
A case of liver cirrhosis: S. S., 52 years old male. He complained hematemesis from the varix of esophagus, and he was operated on esophagean transection.
But bleeding continued severely from the operation site.
He was injected by fresh blood, Factor IX concentrate and fibrinogen as replacement therapy, and Trasylol for stoppage of bleeding.
Unfortunately he complained bleedineg continually, and became anuria finally resulting in expiration, by coagulation disorders.
By autopsy, many microthrombi were found at lung, kidneys, intestines etc.
He was diagnosed disseminated intravascular coagulation syndrome by laboratory coagulation studies and autopsy findings.
Factor IX concentrate contains factor II, VII, IX X and Xa.
When AcG (factor V) was added in the reaction mixture of Factor IX concentrate (Prothrombin-complex by Seegers), thromboplastin and Ca++, much thrombin was yielded. And when Factor IX concentrate was dissolved in 2.5Mol of glycine solution (pH 7.2), and stayed at 4°C for 2.5 months, there was observed much thrombin from factor II activated by factor Xa.
When factor IX concentrate was infused into rabbit, the rabbit was died of DIC with the complication of many microthrombi in the target organs.
Facor IX concentrate (Prothrombin-complex) would be a DIC-inducer when it was infused much amount into the patient, especially with with antiplasmin.
