抄録
White cells contaminating platelet concentrates (PC) were analyzed with respect to the number of contamined red cells. PC were prepared from 200ml whole blood anticoagulated with CPD solution and then stored at 22°C with flat-bed agitation for 3 days under the blood center condition. The white cell count per unit volume in PC was positively proportional to the red cell count per unit volume, but their relationship was not high enough (r=0.70; y=10.97x-8.65; n=118). Some PC with low red cell count contained a large number of contaminated white cells. PC containing red cells below 4×104per mm3 have routinely been delivered to hospitals, in which the mean number of white cell was 2.74×107per PC and platelet yields of 3.33×1010. Light microscopic studies showed that most of the contaminated white cells were recognized as lymphocytes.
The rate of alloimmunization and the incidence of febrile reaction in patients who received passive transfusion of PC were discussed in relation to the absolute number of infused white cells.
