Abstract
A three-year-old spayed female Labrador Retriever presented with a history of nasal hyperkeratosis since 7-months-old. Similar clinical features were recognized in 3 of 9 littermates by the owner. Histopathologic examination revealed marked orthokeratosis and parakeratosis, large keratohyalin granules, vacuolar degeneration, and mainly mononuclear cells infiltration in the superficial dermis. In electron microscopic study, lipid droplet and irregular Odland body were observed. Based on these findings, this dog was diagnosed as having hereditary nasal hyperkeratosis. Topical therapy such as 0.005% calcipotriol (Dovonex) ointment, 0.0002% tacalcitol (Bonalfa) cream, and vaseline were tried, and each agent proved useful.
