Abstract
A 3-year-old, female Bernese Mountain dog presented with multiple nodules, and ulcers on the dorsal trunk and medial thighs, corneal edema, and scleritis. Initially, this dog was treated with antibiotics and prednisolone, but they were ineffective. Histopathologic examination revealed bottom-heavy infiltration of histiocytes without any malignant features. Based on these findings, the dog was diagnosed as having systemic histiocytosis. Previous medications plus griseofulvin as an immunomodulatory drug were administrated, after which dermatological and ophthalmologic symptoms were improved obviously. This dog had been managed for 5 years with sporadic previous treatments and occasional intensive care, and finally died of respiratory failure at 8 years of age. Autopsy was not allowed. To the best of our knowledge, this is the first case report of systemic histiocytosis in Japan.
