Abstract
A 12-year-old neutered male domestic cat was presented with vomiting, lethargy. The cat had 5-month history of multiple cutaneous tumors which had developed as a single cutaneous mass on a hind limb diagnosed as benign mastocytoma by a home veterinarian. Blood smear examination revealed peripheral mastocytosis. Hepatosplenomegaly was not evident by ultrasonographic examination, however cytological assessment of aspirates from the spleen and liver revealed many neoplastic mast cells showing frequent erythrophagocytosis. From these findings the cat was diagnosed as visceral mastocytoma, and then treated with fammotidine and prednisolone. Clinical symptoms had tentatively improved, but anemia had been exacerbated. Thereafter, the neoplastic mast cells in the peripheral blood frequently showed engulfment of erythrocytes and platelets. The cat died on the 26th day.