Hereditary pyogranuloma and vasculitis of the nasal plane was diagnosed in two young Scottish terriers: one from Argentina and one from the United States. To the authors' knowledge, this is the first report of this condition occurring outside of Denmark. In one dog, there was a good response to the concurrent oral administration of prednisolone and cyclosporine.

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A 12-year-old neutered male domestic cat was presented with vomiting, lethargy. The cat had 5-month history of multiple cutaneous tumors which had developed as a single cutaneous mass on a hind limb diagnosed as benign mastocytoma by a home veterinarian. Blood smear examination revealed peripheral mastocytosis. Hepatosplenomegaly was not evident by ultrasonographic examination, however cytological assessment of aspirates from the spleen and liver revealed many neoplastic mast cells showing frequent erythrophagocytosis. From these findings the cat was diagnosed as visceral mastocytoma, and then treated with fammotidine and prednisolone. Clinical symptoms had tentatively improved, but anemia had been exacerbated. Thereafter, the neoplastic mast cells in the peripheral blood frequently showed engulfment of erythrocytes and platelets. The cat died on the 26th day.

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A 9-year-old, male neutered domestic shorthair cat was presented with injury at the hip. The skin was markedly thin and it was easily damaged with minor trauma. Complete blood counts showed anemia and neutrophilia with the left shift. Histopathology revealed severely atrophic epidermis with hyperkeratosis, and atrophic dermis consisted of dispersed collagen fibers. The cat was diagnosed as having acquired skin fragility syndrome. After fifty-four days, the cat suddenly died, and autopsy showed systemic amyloidosis with lipid pneumonia and interstitial nephritis.

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Vesicant chemotherapeutic drugs (e.g. doxorubicin, vincristine, and vinblastine) are often used to treat multicentric lymphoma. A nine-year-old beagle was diagnosed with stage III multicentric lymphoma. The dog was affected by an extravasation after being administered about 1.6 mg of doxorubicin (about one-tenth of the planned dose) using an indwelling needle placed in the right cephalic vein. Immediately after the extravasation was notated, 4 incisions, approximately 5 mm in length each, were made with an 18G needle in order to provide an outlet for leaked doxorubicin. About 5 ml of saline solution was then injected locally to purge the residual fluid. There was swelling after the incisions, but it was temporary. On day 57 of the post extravasation, the entire limb suddenly bulged, followed by an ulcer penetrating the muscle tissue on day 63. However, the ulcer healed by day 126, and there was no sign of skin complications until day 622 of the post-extravasation (i.e., the death of the dog). This case study also validated the modified Villalobos technique (i.e., multi-slit like incisions). Due to the delayed appearance of an ulcer and the overall shorter healing time as seen in this case, it may be suggested that multiple incisions along with the conventional treatment is a very effective treatment procedure for doxorubicin extravasations in dogs.

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