Successful management with pentosane polysulfate sodium of hyperhidrosis in a dog

Abstract

A nine-year-old, spayed female Miniature Schnauzer presented with pruritic behavior on the trunk. The dog had had the behavior since her infancy, and it was exacerbated mainly during summer. The dog showed body wetness presumably due to sweating along with scales, papules, erythema, and alopecia over the body. The skin extension index was 16.6 percent. No abnormality was found in hair examinations or skin scrapings. A histopathologic examination revealed remarkably dilated apocrine glands, as well as follicular atrophy and disorganization of the pale-staining connective tissue. Sweat gland dilation and excessive sweating related to connective tissue fragility was suspected. The dog was treated with pentosane polysulfate sodium, a therapeutic agent for osteoarticular disease in dogs, and body wetness and pruritus were almost eliminated.