A nine-year-old, spayed female Miniature Schnauzer presented with pruritic behavior on the trunk. The dog had had the behavior since her infancy, and it was exacerbated mainly during summer. The dog showed body wetness presumably due to sweating along with scales, papules, erythema, and alopecia over the body. The skin extension index was 16.6 percent. No abnormality was found in hair examinations or skin scrapings. A histopathologic examination revealed remarkably dilated apocrine glands, as well as follicular atrophy and disorganization of the pale-staining connective tissue. Sweat gland dilation and excessive sweating related to connective tissue fragility was suspected. The dog was treated with pentosane polysulfate sodium, a therapeutic agent for osteoarticular disease in dogs, and body wetness and pruritus were almost eliminated.

JAK inhibitor, oclacitinib maleate (Apoquel) was administered to two dogs with canine atopic dermatitis (CAD) as an acute phase therapy. Pruritus quickly disappeared, but dose reduction was not successful. The appropriate approach for infections and allergy had been executed. Recombinant Dermatophagoides farinae allergen Der f 2 and pullulan combined product (Allermmune HDM) was immediately added, and the dose of Apoqeul was shortly reduced. The dogs were well managed with monthly administrations of Allermmune HDM 10 μg for one year without any adverse reactions against the therapy. It is considered that combination therapy of Allermmune HDM along with Apoquel could be effective in the acute phase of CAD.