副腎皮質ホルモンと炎症細胞反応 第5篇Arthus現象に及ぼすDOCAの影響

抄録

The influence of DOCA upon Arthus' phenomenon of sham operated rabbits and adrenalectomized rabbits were studied. The results were as follows:
1) The macroscopic findings of Arthus' phenomenon of the adrenalectomized animals injected with DOCA are markedly greater compared with those of non-operated animals.
2) The microscopic findings of Arthus' phenomenon of adrenalectomized rabbits injected with DOCA were as follows: edema was marked, hyperplasia of arteriols, vaquolar degeneration of endothels, thrombi-formation at the acute stage and plasma cell reactions at reconvalescent stage were considerably marked compared with those of the non-injected adrenalectomized animals.
3) Macroscopic findings of Arthus' phenomenon of sham operated rabbits injected with DOCA were similar to those of the control animals. Only the extent of edema was very wide.
4) Microscopic findings of Arthus' phenomenon of sham operated animals injected with DOCA were as follows: edema was marked; leucocytic reaction was considerably marked, however, it did not form an abscess, and degeneration of collagenous fibers and reactions of blood vessels were not significantly marked.
5) The inflammatory reactions of adrenalectomized animals were markedly suppressed, whereas the reaction became marked after the injection with DOCA, although the degree of reactions was considerably low compared with those of the animal injected with cortisone.
6) If DOCA is used in order to maintain the life of the adrenalectomized animals, the inflammatory reactions of adrenalectomized animals became marked compared with those of non-operated animals. Therefore in an attempt to study the inflammatory reactions of adrenalectomized animals, the method without DOCA is more usful than with DOCA. It was confirmed again that the inflammatory cell reactions of adrenalectomized animals were suppressed.