中枢興奮薬のPentobarbital麻酔に対する拮抗と協力に関する研究

抄録

Cardiazol (C), megimide (MG), methylpropamine (MP) and l-1,2-diphenyl-1-dimethylaminoethan (Spa) were used to study their effects on pentobarbital anesthesia in mice. C and MG were in moderate to large doses, antagonist against pentobarbital for the toxicity and also in the duration of anesthesia. A small dose of pentobarbital protected mice against C or MG convulsion. Small doses of C and MG, however, were found to be synergism to pentobarbital since light anesthesia was prolonged in contrast to the above results. Both MP and Spa were antagonistic against pentobarbital anesthesia while at large doses of MP or Spa synergism occurred and the toxicity was more serious than that of each drug. From these findings it was supposed that some nerve structures of cerebral limbic system might be affected by these central stimulants, resulting in certain condition the decrease in activity of cerebral cortex or brainstem reticular formation.