Pentobarbital麻酔下に於ける中枢興奮薬の作用に対するTridioneの影響

抄録

Antagonism of tridione against cardiazol or megimide was investigated in mice. In pentobarbital-treated mice the two phasic actions of cardiazol or megimide were reported in previous paper and in this paper the influences of tridione on these cardiazol or megimide action were investigated using the same method.
1) Cardiozol-as well as megimide-induced seizures were antagonized by small dose (1-5mg/10g) below those causing obvious neurological depression in mice.
2) Pentobarbital anesthesia was shortened by 1mg of tridione in its duration. This arousal effect of tridione was manifested under light anesthesia after pentobarbital.
3) Arousal effect of tridione in pentobarbital anesthesia was diminished or antagonized by convulsant dosage of cardiazol or megimide.
4) It was discussed that tridione may act cerebral limbic system to cause its depression.