癌患者の術後栄養補給に関する研究

そのI Casein食投与と転移、再発との関係

抄録

To determine the influence of alteration of dietary protein upon metastatic incidence and local recurrence following resection of a simulated colon cancer in rats, the following experiments were carried out. Animals maintained on 18,20,25 and 50per cent casein diets (iso-caloric) subsequent to resection of a simulated colon cancer demonstrated a greater tendency to metastatic incidence and local recurrence of tumor. In contrast, animals maintained on 0,5 and 10 per cent casein diets (isocaloric) subsequent to tumor removal exhibited a lessened incidence of metastases and local recurrence. In other words, the more casein consumed, the greater the incidence and extent of metastases.
Further studies disclosed that if animals maintained on a high protein diet prior to tumor removal were placed on a low casein ration following tumor removal, the local recurrence was not different from that of control animals receiving a low casein diet both before and after tumor removal. Likewise, animals initially receiving a low casein diet followed by a high casein diet after tumor removal exhibited a similar degree of local recurrence to the rats receiving a high casein diet throughout. Further, similar results were obtained with the experimental portal injection of tumor cells.
Since the alrteation of dietary protein seems to affect the course of metastatic development, we must give this careful consideration.