心房におけるThiamine関連化合物の抗カリウム,抗Quinidineおよび抗Acetylcholine作用についての薬理学的研究-特に活性原子団に就ての考察

抄録

Thiamine, thiamine tetrahydrofurfuryl disulfide (TTFD), oxythiamine, oxythiamine propyldisulfide (OTPD), dimethialium and dimethialium propyldisulfide (DMPD) were investigated for their effects on guinea-pig atria in relation to those of potassium, quinidine and acetylcholine.
TTFD and D MPD antagonized the effects of potassium and quinidine on naturally beating atria, though in a high concentration DMPD showed the less active antagonization. This effect of DMPD may be caused by it's depressive action on a sino-atrial node, because an antagonization of DMPD against potassium and quinidine did not dropped down in a high concentration of DMPD on the electrically driven atria. The other thiamine related compounds from TTFD and DMPD showed a less active antagonization against potassium and quinidine.
On -anti-acetylcholine effects of the compounds, oxythiamine, TTFD and DMPD were active, but OTPD, thiamine and dimethialium were less active.
The necessary atom groups in chemical structure of TTFD and DMPD to reveal the anti-potassium and anti-quinidine actions may differ from those to reveal the antiacetylcholine action. And as to the above three kinds of antagonizing effects, TTFD was much more active than thiamine itself. The S-S bond in a chemical structure of TTFD, therefore, may promote the affinity of thiamine for the atrial tissue.