巻号一覧
22 巻 (1970)
- 4 号 p. 485-
- 3 号 p. 315-
- 2 号 p. 143-
- 1 号 p. 1-
- Supplement 号 p. S1-
前身誌
22 巻, 2 号
選択された号の論文の10件中1～10を表示しています
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1970 年 22 巻 2 号 p. e1-
発行日: 1970年
公開日: 2013/02/19
ジャーナル フリー -
第一篇一Cytotoxic Activity Testにおける薬物の白血球減少作用について一竹尾 信男1970 年 22 巻 2 号 p. 143-157
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーSera taken from drug allergy patients, to each sample of which the responsible drug had been added, were tested for their toxic effects on leucocytes obtained from healthy patients in the presence of complements.
The resulting changes in leucocyte counts were as follows
1) The added drugs decreased the counts.
2) Among the seral fractions obtain ed by DEAE-cellulose column chromatography, the γ-G and β2-globulin fractions showed the strongest activity, while the β1-globulin fraction showed a much weaker one.抄録全体を表示PDF形式でダウンロード (2378K) -
第二篇-Cytotoxic Activity Testにおける薬物の白血球傷害作用(Cytotoxicity)について竹尾 信男1970 年 22 巻 2 号 p. 158-168
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーThe drug allergy sera, to each sample of which the responsible drug had been added, were examined as to their cytotoxic activity by means of the dye-exclusion technique. The results obtained were as follows:
1) Some of the sample displayed hi g h cytotoxicity even without the responsible drug, a condition which suggests the presence of auto-immune anti-leucocyte antibodies in these particular sera.
2) The addition of responsible drugs markedly elevated the cytotoxicity of the drug allergy sera.
3) Fr actionation by DEAE-cellulose column chromatography revealed that the 2"globulin fraction had the highest activity among the fractions, followed by the (32-globulin which had a much weaker activity.
4) Histamine cytotoxicity was estimated in normal serum to which various amounts of crystalline histamine and normal human leucocytes had been added.
The result suggested that the cytotoxic activity of drug a llergy sera should be equivalent to that of histamine concentrations of not less than 1.0x10-14g.抄録全体を表示PDF形式でダウンロード (2828K) -
第三篇-白血球蛋白感作カオリン凝集反応竹尾 信男1970 年 22 巻 2 号 p. 169-185
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーIn order to detect complete or incomplete antibody-like activities in drug allergy sera and also in their fractions, means of detecting agglutination reaction of kaolin particles in saline or albumin solutions were designed and carried out, i. e. the kaolin particles were first coated with leucocyte proteins. Furthermore, the influence of the papainization of the leucocytes used for the coating was also studied in order to differentiate autoantibody from iso-antibody using the method of van Loghem et al. The results were as follows:
1) C omplete antibody-like activity was detected in about 80% of the drug allergy sera. Fractionation of the sera revealed that this activity was mainly associated with the r globulin and 02-globulin fractions, and only slightly with the 01-globulin fraction.
2) In albumin solution of the drug allergy sera, the activities displayed were inconsistent.
3) The influence of leucocyte papainization on the activity of the serum protein fractions was most markedly seen in the r- and 02-globulin fractions.
These results suggest the presence of a multiplicity of an tibody-like factors in the drug allergy sera, i. e. complete, incomplete, auto-, and iso-antibody-like activities.抄録全体を表示PDF形式でダウンロード (3703K) -
第四篇-アレルギー性疾患,とくに気管支喘息におけるCytotoxic Activity Testを用いるアレルゲンの検出法竹尾 信男1970 年 22 巻 2 号 p. 186-193
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーBoth cytotoxic and cytolytic activities in the presence of allergens in sera samples obtained from bronchial asthma patients were studied by means of the dye-exclusion technique. The results obtained were as follows:
1) The sera showed high cytotoxic activity brou ght on by the addition of the responsible allergens.
2) The leucocyte counts were markedly decreased in vitro by the addition of the responsible allergens.
These resu lts suggest that bronchial asthma patients not only have the well-known skin sensitizing antibodies, but also seral antibodies as well.抄録全体を表示PDF形式でダウンロード (1320K) -
第1編・Mucoraceaeに属する3種の真菌による鳩の経気道感染実験北村 里子1970 年 22 巻 2 号 p. 194-203
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーBy 3 days-long inhalation of the air containing the spores of Absidia ramosa, Rhizopus oryzae or Mucor pusillus respectively in high concentration, ten pigeons were subjected to experimental mucormycosis. All pigeons showed neither remarkable weight-loss, nor clinical symptoms or signs including anorrhexia and diarrhea in 5 or 12 days clinical observation after inoculation.
All pigeons were sacrified at 5 or 12 days after inoculation and subjected to autopsy. A marked bleeding was observed in gross examination on the surface of lungs, while no remarkable gross findings in heart, liver, spleen, kidneys and G. I. -tracts in all cases inoculated with 3 strains respectively.
Histological examination revealed a moderate or marked bleeding in bronchus, bronchioles and also pulmonary parenchyma with a few hyphal elements. As to the intensity of bleeding, the Absidia ramosa inoculated group showed much marked bleeding than the groups inoculated with Rhizopus oryzae or Mucor pusillus. Generally speaking, inflammatory responses such as edema or cellular infiltration were less predominant in all groups. The giant cell response around the hyphal elements was observed in only one pigeon inoculated with Absidia ramosa at 12 days after inoculation. The other organs were not remarkable on microscopic study. Namely, it seemed that the pigeons transtracheally inoculated with spores of 3 genera of Mucoraceae respectively failed to develop systemic mucormycosis by the method used in this experiment. Positive cultures of respective strain were obtained from the lungs, but not from the other organs in all pigeons.抄録全体を表示PDF形式でダウンロード (3392K) -
申川 満1970 年 22 巻 2 号 p. 204-219
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーAn apparatus based on the electrical modification of "Mangold's Myotonometer" which gave a continuous estimate the muscle consistency, was used to measure one of the biceps brachii and gastrocunemius muscles in the premature infants.
Thirty premature infants, consisting of 13 males and 17 females, served as test subjects during first 4 weeks after birth.
1. At several hours after birth, the biceps brachii muscle has a harder consistency than the gastrocunemius, but after first week-old there was no difference between two muscles.
2. The muscle consistency of the biceps brachii presented harder at the extensive position than at the flexion. This contrary results to expectation seemed to be due to the difference between the passive and the active flexion.
3. With respect to the maturity, the muscle consistenc y didn't depend on the birth weight, but largely on the duration of pregnancy: i. e. the shorter the duration, the harder the consistency.
4. The develo pment of the muscle consistency presented that the consistency by the 5 th day was soft and by 1st to 2 nd week that hardness increased. This hardne s s showed a tendency to decrease after 4 week-old and finally reached a fairly stable level. That findings have great resemblance to the one of the mature infants, but presented slower development in the premature infants.
5. Thickness of the subcutaneous tissue didn't act on the measurement of the muscle consistency, because it was almost fixed during first 4 weeks after birth.抄録全体を表示PDF形式でダウンロード (2497K) -
衣川 磐1970 年 22 巻 2 号 p. 220-233
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーThiamine, thiamine tetrahydrofurfuryl disulfide (TTFD), oxythiamine, oxythiamine propyldisulfide (OTPD), dimethialium and dimethialium propyldisulfide (DMPD) were investigated for their effects on guinea-pig atria in relation to those of potassium, quinidine and acetylcholine.
TTFD and D MPD antagonized the effects of potassium and quinidine on naturally beating atria, though in a high concentration DMPD showed the less active antagonization. This effect of DMPD may be caused by it's depressive action on a sino-atrial node, because an antagonization of DMPD against potassium and quinidine did not dropped down in a high concentration of DMPD on the electrically driven atria. The other thiamine related compounds from TTFD and DMPD showed a less active antagonization against potassium and quinidine.
On -anti-acetylcholine effects of the compounds, oxythiamine, TTFD and DMPD were active, but OTPD, thiamine and dimethialium were less active.
The necessary atom groups in chemical structure of TTFD and DMPD to reveal the anti-potassium and anti-quinidine actions may differ from those to reveal the antiacetylcholine action. And as to the above three kinds of antagonizing effects, TTFD was much more active than thiamine itself. The S-S bond in a chemical structure of TTFD, therefore, may promote the affinity of thiamine for the atrial tissue.抄録全体を表示PDF形式でダウンロード (5804K) -
松田 久子1970 年 22 巻 2 号 p. 234-265
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーAcute and subacute toxicities induced by the intravenous administration of Formosan snake venoms, the venoms of Agkistrondon acutus (Gunther) and Trimeresurus mucrosquamatus (Cantor), were toxicologically studied in comparison with the shock induce d by ATP or insulin regarding the changes in hematometry, proteinogram, and histological figure on rabbits as follows:
1) When the sn a ke venom was intravenously administered in a toxic dose, lymphopenia and anemia were observed for more a week. But, lymphopenia induced by ATP or insulin in each shock dosage also lasted for several days.
2) Lymphopenia induced by the snake venoms is assum ed to be brought about through the acceleration of function of hypophysis and adrenal cortex.
3) a 2-Globulin was increased in subacute stages of the snake venom toxicosis, but was scarcely changed in any stage of ATP or insulin shock.
4) The snake venoms caused the degeneration of glomerul i and tubules in kidney, of which Trimeresurus venom caused remarked changes. From these results, it has been clarified that each snake venom is not only a shock poison but also a nephrotoxic substance.抄録全体を表示PDF形式でダウンロード (6845K) -
鮫島 美子, 笹川 美年子1970 年 22 巻 2 号 p. 266-274
発行日: 1970/06/20
公開日: 2013/02/19
ジャーナル フリーLiver function test was made and liver tissues were examined histologically in cases of diabetes mellitus hospitalized at the Second Department of Internal Medicine, Kansai Medical School Hospital during May 1966 and April 1969.
Those cases totaled 107, accunting for 6.3% of all the cases admitted in the period. Serious cases showed a slight increase in icterus index, alkaline phosphatase and cholesterol, revealing abnormalities in cobalt reaction and cadmium reaction.
Sixty-one cases (57%) of the 107 cases had at least one item found abnormal in liver function tests. Histologically, liver biopsy revealed a vacuolization of the liver cell and nucleus, a fatty infiltration in the liver lobules, and a proliferation of connective tissue in the portal area, in correspondence to the degree of severity. A portal cirrhosis was also observed in one autopsy case.
Out of a total of 1531 in-pat ients in the same period,107 cases (6.3%) were diabetes mellitus,35 cases (2.3%) were liver cirrhosis, and nine cases were diabetes mellitus complicated with liver cirrhosis which proved to be statistically significant.
Twelve of the 35 liver cirrhosis cases (34.3%) were heavy dr inkers as were seven of the nine cases (77.8%) which showed diabetes mallitus complicated with liver cirrhosis. It was supported to assume that in-take of alcohol significantly influenced the development of cirrhosis in the liver in cases of diabetes mellitus.抄録全体を表示PDF形式でダウンロード (3708K)
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