Choline was appointed an essential nutrient in 1998 by the National Academy of Science and The dietary reference intake was evaluated scientifically in Nutrients Food and Nutrition Board Institute of Medicine. Choline is trimethyl aminoethanol of a quaternary ammonium ion constituting choline-phosholipids such as sphingomyelin, phosphatidylcholine or Glycerophosphocholine. Choline is a hydrophilic base moiety of the phosholipids building a cell lipid bilayer. Particularly, choline-phosholipids is the construction materials of lipid monolayer giving lipoprotein and a mother's milk fat globule and therefore is a basic material of the lipid nutrition. Choline functions as a precursor for acetylcholine, choline-phosholipids, and methyl donor betaine. The primary criterion used to estimate the adequate intake for choline is the prevention of liver damage as assessed by measuring serum alanine aminotransferase levels. A nutrient lipid-based in these general remarks in our country: We want to suggest the problem to make Choline widely available.