Genes and lipid nutrition of Mongoloid are different from those of Caucasoid. Westernization of Mongoloids resulted in increase of diseases related to lipid metabolism including diabetes and atherosclerosis. The Mongoloid-specific genetic factor is mainly composed of single nucleotide polymorphism (SNP). Those SNPs saving energy and induce diabetes are called "thrifty SNPs", and include b-adrenergic receptor (b3AR), uncoupling proteins (UCPs)1 and 2, and UCP promoter (UCP3p), PPAR-g2, leptin receptor (LEPR) etc. These SNPs constitute obesity-prone genetic factors of Mongoloids under Westernized dietary habits. We studied these SNPs in Mongoloid living in Japan, Okinawa, Palau, Thai, China, Tonga and Mongol (Biochem. Biophys. Res. Commun. 295: 207-222, 2002). We also analyzed SNPs of the patients in our Nutrition Clinic, who were educated 25-31 years before. Despite differences in these SNPs, the special dietary habits (four-group point method) and exercise prevented most of the lifestyle related diseases.
