都民公開講座
Tailor-Made Medicine for Colorectal Cancer
キーワード:
tailor-made medicine,
colorectal cancer,
anti-EGFR monoclonal antibodies,
RAS mutation,
UGT1A1
2016 年 62 巻 1 号 p. 13-16
詳細
2016 年 62 巻 1 号 p. 13-16
In chemotherapy for colorectal cancer, the therapeutic effects of anti-epidermal growth factor receptor (EGFR) drugs can be predicted based on the RAS genetic type, while adverse events of irinotecan are predictable based on gene polymorphism of UGT1A1, an enzyme that metabolizes irinotecan. Such personalized medication based on the characteristics of each case of colorectal cancer is referred to as “tailor-made medicine”. This therapeutic approach is likely to improve the efficacy of treatment, decrease adverse events, improve safety, and reduce medical expenses.
