Etiology of Insulin Resistance in Asian Non-Obese Subjects -Juntendo Sportology Center Core Study-

抄録

Obesity and its associated metabolic disorders are rapidly disseminating all over the world. While they became serious health problem, such diseases in Asians shows different features from those in other races such as Caucasian and African. One of the important features is a susceptibility to develop to type 2 diabetes even without excess body mass index. To search for the mechanism underlying this feature is important to find the suitable therapeutic strategy for Asian obesity. Thus, as a core study of the Sportology Center of Juntendo University Graduate School of Medicine, we assessed tissue-specific insulin resistance in Japanese non-obese subjects. In this study, we recruited non-obese and non-diabetic Japanese subjects and measured insulin sensitivity in muscle and liver by a 2-step hyperinsulinemiceuglycemic clamp with glucose tracer and ectopic fat content in muscle and liver by proton magnetic resonance spectroscopy. So far, our data suggests that muscle insulin resistance may play a central role in future onset of the diseases that could make the healthy people to disable people.