Maternal Treatment with MCI-186 Does Not Improve Delayed Deterioration of Cellular Bioenergetic State and Mitochondrial Activity Following Transient Intrauterine Ischemia in the Fetal Rat Brain

Akishige Yokota; Akihito Nakai; Yoshinari Taniuchi; Naotaka Okuda; Masako Nakai; Toshiyuki Takeshita

doi:10.1272/jnms.72.127

Short Communication

Maternal Treatment with MCI-186 Does Not Improve Delayed Deterioration of Cellular Bioenergetic State and Mitochondrial Activity Following Transient Intrauterine Ischemia in the Fetal Rat Brain

Akishige Yokota, Akihito Nakai, Yoshinari Taniuchi, Naotaka Okuda, Masako Nakai, Toshiyuki Takeshita

著者情報

キーワード: mitochondrial respiratory activity, energy metabolism, intrauterine ischemia, fetal brain, hydroxyl radical, MCI-186

ジャーナルフリー

2005 年 72 巻 2 号 p. 127-130

DOI https://doi.org/10.1272/jnms.72.127

詳細

抄録

The mitochondrial respiratory activities and energy metabolism in the fetal rat brain were measured at the end of 30 minutes of intrauterine ischemia and after 2 and 4 hours of recirculation. The transient ischemia was associated with a delayed deterioration of cellular bioenergetic state and mitochondrial activities. The deterioration was not prevented by a free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186), given immediately after recirculation.

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