Pathophysiology of Functional Dyspepsia

Seiji Futagami; Mayumi Shimpuku; Yan Yin; Tomotaka Shindo; Yasuhiro Kodaka; Hiroyuki Nagoya; Shoko Nakazawa; Mayumi Fujimoto; Nikki Izumi; Noriko Ohishi; Tetsuro Kawagoe; Akane Horie; Katsuhiko Iwakiri; Choitsu Sakamoto

doi:10.1272/jnms.78.280

Review

Pathophysiology of Functional Dyspepsia

Seiji Futagami, Mayumi Shimpuku, Yan Yin, Tomotaka Shindo, Yasuhiro Kodaka, Hiroyuki Nagoya, Shoko Nakazawa, Mayumi Fujimoto, Nikki Izumi, Noriko Ohishi, Tetsuro Kawagoe, Akane Horie, Katsuhiko Iwakiri, Choitsu Sakamoto

Author information

Seiji Futagami
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Mayumi Shimpuku
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Yan Yin
Division of Gastroenterology, Department of Internal Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province
Tomotaka Shindo
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Yasuhiro Kodaka
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Hiroyuki Nagoya
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Shoko Nakazawa
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Mayumi Fujimoto
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Nikki Izumi
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Noriko Ohishi
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Tetsuro Kawagoe
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Akane Horie
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Katsuhiko Iwakiri
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
Choitsu Sakamoto
Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School

Keywords: functional dyspepsia, gastric emptying, ghrelin, post-infectious functional dyspepsia

JOURNAL FREE ACCESS

2011 Volume 78 Issue 5 Pages 280-285

DOI https://doi.org/10.1272/jnms.78.280

Details

Abstract

Functional dyspepsia is a highly prevalent and heterogeneous disorder. Functional dyspepsia involves many pathogenic factors, such as gastric motility disorders, visceral hypersensitivity, psychological factors, Helicobacter pylori infection, and excessive gastric acid secretion. The present article provides an overview of pathogenetic factors and pathophysiologic mechanisms.

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