Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells

Yoko MIURA; Masayoshi OYAMA; Kazuhiro IGUCHI; Tetsuro ITO; Misako BABA; Yuji SHIKAMA; Shigeyuki USUI; Kazuyuki HIRANO; Munekazu IINUMA; Hiroshige MIKAMO

doi:10.3177/jnsv.61.201

Note

Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells

Yoko MIURA, Masayoshi OYAMA, Kazuhiro IGUCHI, Tetsuro ITO, Misako BABA, Yuji SHIKAMA, Shigeyuki USUI, Kazuyuki HIRANO, Munekazu IINUMA, Hiroshige MIKAMO

著者情報

Yoko MIURA
Department of Infection Control and Prevention, Aichi Medical University
Masayoshi OYAMA
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
Kazuhiro IGUCHI
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
Tetsuro ITO
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
Misako BABA
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
Yuji SHIKAMA
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
Shigeyuki USUI
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
Kazuyuki HIRANO
Laboratory of Pharmaceutics, Gifu Pharmaceutical University
Munekazu IINUMA
Laboratory of Pharmacognosy, Gifu Pharmaceutical University
Hiroshige MIKAMO
Department of Infection Control and Prevention, Aichi Medical University

キーワード: epimedium herb, anti-androgenic activity, icarisid II, flavonoid glycoside

ジャーナルフリー

2015 年 61 巻 2 号 p. 201-204

DOI https://doi.org/10.3177/jnsv.61.201

詳細

抄録

Anti-androgens are regarded as potential therapeutic agents for the treatment of prostate cancer. We determined that an epimedium herb (EH) extract exhibited anti-androgenic activity in a luciferase assay using androgen receptor-positive prostate cancer LNCaP cells. Nine EH-derived flavonoids were examined. The results identified icarisid II as a very potent anti-androgenic EH-derived flavonoid. A quantitative RT-PCR analysis confirmed that the flavonol suppressed the expression of the androgen-responsive KLK3 gene.

責任著者(Corresponding author)

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