EFFECT OF α-TOCOPHEROL ON THE BINDING OF BENZO(A)PYRENE TO NUCLEAR MACROMOLECULES

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The binding of metabolically activated ¹⁴C-benzo(a)pyrene (BP) to rat liver nuclei was studied. The nuclear framework structure, termed the nuclear matrix, was found to bind BP preferably. α-Tocopherol inhibited the binding of BP to nuclear macromolecules in the presence of phenobarbital (PB)-induced microsomes. α-Tocopherol decreased the level of BP metabolites in nuclei, though it did not inhibit the activation of BP by PB-induced microsomes.