Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
Effects of Carbon Dioxide on Serum Biochemical Patterns and on Histopathological Changes of Organs in Rats
滿田 久輝上野 三郎水野 洋上田 忠司藤川 広美野原 智子深田 千枝子
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1982 年 28 巻 2 号 p. 105-115

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The effects of carbon dioxide on serum biochemical patterns and on histopathological changes of organs were studied in male Sprague-Dawley rats which were anesthetized with a mixture of 40% carbon dioxide and 60% oxygen for 3 hr. This level of carbon dioxide is sufficient to maintain rats at an anesthetized level. There were gradual decreases in respiration, body temperature, heart rate, blood pressure and blood pH. At the same time there were significant increases in organ weight (lungs and kidneys), and in exudate to thorax, hematocrit, and serum biochemi-cal patterns (glucose, phosphorus, uric acid, blood urea nitrogen, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and a-hydroxy-butyrate dehydrogenase). The weight of the liver, however, decreased slightly. There were minor abnormalities in both gross anatomy and histology (lungs, liver and kidneys). When the rats inhaled ordinary air, they awoke within a few minutes and recovered normal hematological levels (pH 7.3, PaO2 120 mmHg and PaCO2 45 mmHg) within 24hr.
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