巻号一覧
28 巻, 2 号
選択された号の論文の11件中1～11を表示しています
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岡田 美津子, 近藤 孝司1982 年 28 巻 2 号 p. 69-75
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーIn rat liver, 90% of the aspartate aminotransferase is present as the holoenzyme. In pyridoxine deficiency, the ratio of holoenzyme activity to total activity is markedly reduced, but after pyridoxine injection it was found to rapidly increase, although the total enzyme activity remained low for a few days. The activities of aspartate aminotransferase isozymes in pyridoxine-deficient rat tissues and the effect of pyridoxine treatment on their activities were examined. The intestinal enzyme acti-vities of pyridoxine-deficient rats were readily reconstituted in the presence of pyridoxal phosphate in vitro, but the enzyme activities in liver and muscle in the deficient rats required several days for complete recovery, suggesting that active enzyme was synthesized de novo in these tissues.抄録全体を表示PDF形式でダウンロード (640K) -
岩見 玉子, 岡田 美津子1982 年 28 巻 2 号 p. 77-84
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーThe effect of pyridoxine deficiency on cholesterol cata-bolism was studied in rats. The concentrations of bile lipid components were higher in pyridoxine-deficient rats than in controls. A decreased ratio of taurine to glycine conjugates was observed in the deficient rats. No change in the neutral sterol content, but an increase in the bile acid content of the feces was observed in the deficient rats. Increased cholesterol catabolism in pyridoxine-deficient rats was also shown by the shorter half-life of the [14C]cholesterol injected into these animals.抄録全体を表示PDF形式でダウンロード (848K) -
D. SADAVA, D. WATUMULL, K. SANDERS, K. DOWNEY1982 年 28 巻 2 号 p. 85-92
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーMale rabbits were injected intraperitoneally for five con-secutive days with one of the following: (A) 0.3ml/kg dimethyl ethylene glycol (solvent); (B) 40 mg/kg cholesterol and 8mg/kg ergocalciferol in solvent; (C) same regimen as B with the addition of 150 mg/kg ascorbic acid in water. Daily blood samples were taken for determination of cholesterol and triglycerides, and for lipoprotein electrophoresis. After 5 days of injections, histological sections were made of the aorta at the arch. After 5 days, group B, as compared with group A, had higher serum cholesterol (150mg/dl vs. 50 mg/dl, p<0.005), higher serum triglycerides (650mg/dl vs. 150mg/dl, p<0.01), and lower high-density lipoprotein (16% vs. 35%, p<.05). On autopsy, discontinuous elastic fibers and intimal damage were seen in sections of the aortas from group B, but not from group A. After 5 days, group C had control levels of cholesterol (55mg/dl) and triglycerides (160mg/dl), and no significant difference from the control lipoprotein profile. Injections of cholesterol alone showed a slight induction of aortic lesions and blood chemistry changes. No alterations in these parameters were induced by ergocalciferol alone. The data indicate a prophylactic effect of vitamin C on the biochemical and histological changes rapidly induced by cholesterol and ergocalciferol.抄録全体を表示PDF形式でダウンロード (1061K) -
月田 潔, 斎木 加代子1982 年 28 巻 2 号 p. 93-103
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーAll-trans biscyclohexylammonium retinylphosphate was synthesized using bis(triethylammonium)phosphate as the phosphate donor. It was shown to be pure from physico-chemical evidence including ultraviolet, infrared, 1H- and 13C-nuclear magnetic resonance and mass spectrometry. In contrast to previous reports, the synthesized product is quite stable toward alkaline hydrolysis. Direct or iodine-catalyzed photo-isomerization of the all-trans compound can produce the corresponding 13-cis isomer. Simultaneous quantification of cis-trans stereoisomeric retinylphosphates was demonstrated by ion-pairing reversed-phase liquid chromatography with an isocratic mobile phase consisting of aqueous methanol and with ultraviolet detection at 300 nm. The mobile phase also contains tetrabutylammoniumphosphate as the counter-ion. The feasibility and extent of stereoisomerization of all-trans retinylphosphate have been compared with those of carotenoidal and retinoidal polyenes.抄録全体を表示PDF形式でダウンロード (888K) -
滿田 久輝, 上野 三郎, 水野 洋, 上田 忠司, 藤川 広美, 野原 智子, 深田 千枝子1982 年 28 巻 2 号 p. 105-115
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーThe effects of carbon dioxide on serum biochemical patterns and on histopathological changes of organs were studied in male Sprague-Dawley rats which were anesthetized with a mixture of 40% carbon dioxide and 60% oxygen for 3 hr. This level of carbon dioxide is sufficient to maintain rats at an anesthetized level. There were gradual decreases in respiration, body temperature, heart rate, blood pressure and blood pH. At the same time there were significant increases in organ weight (lungs and kidneys), and in exudate to thorax, hematocrit, and serum biochemi-cal patterns (glucose, phosphorus, uric acid, blood urea nitrogen, glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and a-hydroxy-butyrate dehydrogenase). The weight of the liver, however, decreased slightly. There were minor abnormalities in both gross anatomy and histology (lungs, liver and kidneys). When the rats inhaled ordinary air, they awoke within a few minutes and recovered normal hematological levels (pH 7.3, PaO2 120 mmHg and PaCO2 45 mmHg) within 24hr.抄録全体を表示PDF形式でダウンロード (854K) -
菅野 道廣, 池田 郁男, 今泉 勝己, 渡辺 美登里, 安藤 美穂1982 年 28 巻 2 号 p. 117-126
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーMale rats were fed on semipurified cholesterol-free diets containing butter fat with or without supplementary β-sitosterol. The expected rise of serum cholesterol caused by butter fat, as compared with safflower oil, was not able to be demonstrated, and hence the hypo-cholesterolemic effect of β-sitosterol as well. However, the plant sterol effectively lowered the liver cholesterol level. Similar responses were also observed in mice. The distribution of cholesterol in serum lipoproteins remained unchanged among different dietary regimens. Butter fat in-creased the concentration of serum apoA-I in relation to safflower oil. There was possibly a trend toward higher serum apoA-I with sup-plementation of β-sitosterol in a butter-fat diet. The effect of the plant sterol on serum apoB was rather variable. The observation strongly suggests that alteration in cholesterol metabolism in these rodents may not satisfactorily be estimated by the serum cholesterol parameter alone when diets free of cholesterol are fed. The concentration of hepatic cholesterol and serum apolipoproteins seems a more apposite measure for this purpose.抄録全体を表示PDF形式でダウンロード (1071K) -
不破 英次, David V. GLOVER, 杉本 温美, 井川 佳子, 高谷 友久1982 年 28 巻 2 号 p. 127-138
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーStarches of the opaque-2, sugary-2 opaque-2 and waxy opaque-2 endosperm mutants of two broad-based synthetic cultivars (Temp HA and Temp HB) of maize adapted to the more temperate areas of the world are, in general, similar to the respective starches of inbred maize background with regard to amylose percentage and the distribution of linear α-D-(1→4) linked unit-chains of amylopectin, starch-granule susceptibility to amylases, and properties examined by X-ray diffracto-metry and photopastegraphy. Changes in starch content and morphology of starch granules by scanning electron microscopy in dissected endo-sperms of the two broad-based synthetic maize cultivars following germi-nation 0, 2, 4 and b days after planting were also investigated.抄録全体を表示PDF形式でダウンロード (1982K) -
高橋 因, 水沼 俊美, 岸野 泰雄1982 年 28 巻 2 号 p. 139-147
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーTransfer of lipid to the lymph by the intestine was studied in rats fed on choline-deficient or choline-supplemented diet for 2 weeks. In choline-deficient rats, lymph output was reduced. Choline deficiency impaired the incorporation of glycerol tri[l-14C]oleate into triglyceride in the lymph. The triglyceride level in lymph lipoproteins was lower in choline-deficient rats than in controls. Ultrastructural studies suggested that impaired release of lipoproteins was responsible for accumulation of fat in intestinal absorptive cells. These defects are probably related to changes in the membrane system of the intestine and to a failure in lipid droplet movement within absorptive cells, resulting from alterations in the microfilaments. Oral administration of phosphatidylcholine to rats on choline-deficient diet rapidly improved the decreased lymph output and the impaired incorporation of glycerol tri[l-14C]oleate into triglyceride and reduced fat deposition in intestinal epithelial cells. In conclusion, phos-pholipids such as choline are confirmed as being extremely important in the absorption of fat by the possible mechanism of fat transport across the membrane.抄録全体を表示PDF形式でダウンロード (1505K) -
村松 敬一郎, 石田 眞裕1982 年 28 巻 2 号 p. 149-162
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーA study was undertaken to measure the ability of rats to regulate amino acid intake by means of a self-selection method. Weanling rats were simultaneously offered a choice between a 10% casein diet or a 10% amino acid mixture diet lacking methionine or lysine and a 10 casein diet containing different levels of methionine or lysine over 2 weeks. Weight gain and food consumption of rats allowed a choice between the two diets were much greater than those of animals fed on the fixed diets with high levels of methionine or lysine added, and the self-selecting rats had the ability to take in amounts of methionine or lysine appropriate to meet the requirement. Methionine intakes of self-selecting rats were kept to a relatively narrow range (41-100 mg/day), but lysine intakes of self-selecting rats were wide-ranging (86-300 mg/day). It was demonstrated that methionine or lysine intake is closely regulated in rats given a choice of diets containing varied levels of methionine or lysine.抄録全体を表示PDF形式でダウンロード (1216K) -
江指 隆年, 鈴江 録衣郎, James H. LEATHEM1982 年 28 巻 2 号 p. 163-172
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーStudies were made on the effect of protein-free diet (PFD) feeding and on recovery from PFD feeding on sex organ weight, serum testosterone, pituitary prolactin and pituitary growth hormone content of young (4 months old) and old (18 months old) male rats.
After 20 days of protein depletion, the testis weight remained almost the same, but the ratio of testis weight to body weight was higher in the lower age group, demonstrating a greater resistibility to protein deficiency in young rats. The weight of the seminal vesicle and prostate decreased on ingestion of PFD in both age groups, but a more marked increase was shown in refed young rats.
Feeding of PFD for 20 days significantly reduced pituitary prolactin, pituitary growth hormone and serum testosterone in both age groups. Refeeding of protein increased these hormones, but a more marked increase was also observed in the younger group. These results seem to support the hypothesis that one of the important characteristics of an aging organism is its reduced capacity to adapt to environmental changes.抄録全体を表示PDF形式でダウンロード (785K) -
柴田 克己, 本岡 和美, 村田 希久, 岩井 和夫1982 年 28 巻 2 号 p. 173-177
発行日: 1982年
公開日: 2009/04/28
ジャーナル フリーPDF形式でダウンロード (558K)
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