Effects of α-Tocopherol-Nicotinate Administration on the Microdynamics of Phospholipids of Erythrocyte Membranes in Human Subjects

抄録

The effects of α-tocopherol-nicotinate on the microdynamic parameters, membrane viscosity, and wobbling angle of phospholipid molecules of healthy human erythrocyte membranes were studied with a nanosecond time-resolved fluorometer. The incorporation of α-tocopherol was achieved by oral administration of α-tocopherol-nicotinate for one month with dosage of 400mg/day. The increase in a-tocopherol con-centration in erythrocytes was confirmed in two subjects. The membrane viscosity in seven healthy subjects decreased significantly from 1.015±0.137 to 0.888±0.133 mPas. But no changes in the wobbling angle of phospholipid molecules were observed.