抄録
To evaluate the adequacy of maternal pyridoxine supple-mentation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP+PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3mg pyridoxine⋅HCl (PN⋅HCl)/d during pregnancy. Maternal PN⋅HCl supplementations were positively correlat-ed to both maternal (r=0.62) and cord (r=0.78) plasma PLP concentrations (p<0.0001). Mothers supplemented with 2 or 3mg/d PN⋅HCl had significantly higher plasma concentrations of PLP and total B6 aldehyde vitamer in maternal and cord blood compared with those receiving 0 or 1 mg PN⋅HCl/d. A growth benefit for neonates whose mothers had maternal and cord plasma PLP concentrations≥40nM was revealed by the maternal supplementation of 2mg PN⋅HCl/d during pregnancy. Thus, in healthy pregnant women, according to our study, a daily supplement of 2 mg PN⋅HCl provides the adequacy of maternal and neonatal vitamin B6 status and the satisfactory growth of neonates at birth.
