Abstract
There are currently no effective therapies for severe atopic dermatitis except for the administration of glucocorticoids or immunosuppressants which have several severe side effects. The transfection of cis-element double-stranded oligodeoxynucleotides (ODNs), reffered to as “decoy”, has been reported to be a powerful tool and a new type antigen treatment strategy for gene therapy and for study gene transfection. We discussed STAT6 decoy ODN can also inhibit the late phase reaction as an atopic dermatitis mouse model. We also discussed that STAT6 decoy ODN ointment is very effective for the treatment of atopic dermatitis in the clinical studies. (Online only)
