In each patient, we treated Xanthoelasma with the traditional surgical excision and the CO₂ laser treatment. We compared the utility of the two procedures for the treatment of Xanthoelasma.
The clinical result is equally improvement between the two treatments.
Both treatments were well tolerated by all patients, cosmetically.
We found no significant difference in the treatment result and the recurrence rate between the two procedures.
To achievet the excellent outcomes by the surgical excision, we need the experienced surgical skills. (V-Y advancement flap, Dufourmental flap etc.)
But, technique of CO₂ laser provides a safe, easily and effective treatment for xanthoelasma. (Online only)

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In our hospital, verruca patients are 4% out of 964 out-patients for a month. Patients under 10 years old are 27%, those under 20 years old are 17% which makes 50%.
Therapies are consist of cryotherapy by liquidfied nitrogen for 62%, monochrorcacetic acid for 23%, salicylic acid combination with cryotherapy for 15%. Duration of therapy is within a month for 29%, within 3 months for 15%, over a year for 8%.
Historically therapy for viral warts proceeded cyotherapy on nineteen sixties, intralesional bleomycin injection , gultalaldehyde, topical 5 FU, DNCB sensitization for Nineteen seventies, LASER therapy for nineteen eighties. Painless therapy started to be considered from nineteen seventies. Those include gultalaldehyde, monochloroacetic acid, 5 FU, DNCB.
Preceding glutalaldehyde therapy was changed because of its difficulties for treat to monochloroacetic acid. It showed excellent outcome for every week's therapy. Some irritation and pain are troubles. Recently topical vitamin D3 therapy is tried for painless therapy. (Online only)

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Cullus and clavus are very common skin disorders, but are frequently resistant against many treatments. Various factors including shape of individual's foot are playing an important role to induce such lesions. In addision, several clinically similar lesions including warts which present a hyperkeratotic appearance on the soles should be differentiated. To prevent callus and clavus, therefore, it is necessary to establish a useful and practical methods except shaving the lesions, and one recommended idea may be an establishment of the specialists like DPM (Doctor of Podiatric Medicine) and/or Podiatrist who are well trained for prevention and treatment of these lesions. (Online only)

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Pityriasis rosea Gibert (PR) has its own characteristic clinical features and course, and most commonly occurs from adolescence to the thirties. Two herpes viruses, HHV-6 and HHV-7 have been suggested to be potent infectious agents. Conventional drug therapy and UV phototherapy do not affect the duration of the disease.
Though PR is a self-limited disease, its rapid progress and numerous erythematosquamous lesions on the trunk have a negative impact on patients and cause severe anxiety. In our clinic, we educate them by explaining the presumptive course, lack of communicability and good prognosis. The basic policy to treat patients is just watchful waiting. Of course if they have pruritus, we may prescribe anti-histamine and/or topical corticosteroid ointments.
We evaluated 56 patients who visited our clinic from October 2004 through April 2006. They consisted of 9 males and 47 females from 9 to 71 years old (mean: 33.9 y.o).
After our explanation, 45 patients did not want any drug. Four of them (4/45; 8.9%) revisited and complained of pruritus. These included one of 8 patients with moderate to severe pruritus, three of 21 patients with mild pruritus, and none of 16 patients without pruritus. For 11 patients who needed drug therapy, one (1/11; 9.1%) with severe pruritus, made a second visit to continue the treatment. In conclusion, we suppose that most patients can follow our regimen for PR. However, a few patients who come just after onset should be treated to prevent worse itching. (Online only)

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There are currently no effective therapies for severe atopic dermatitis except for the administration of glucocorticoids or immunosuppressants which have several severe side effects. The transfection of cis-element double-stranded oligodeoxynucleotides (ODNs), reffered to as “decoy”, has been reported to be a powerful tool and a new type antigen treatment strategy for gene therapy and for study gene transfection. We discussed STAT6 decoy ODN can also inhibit the late phase reaction as an atopic dermatitis mouse model. We also discussed that STAT6 decoy ODN ointment is very effective for the treatment of atopic dermatitis in the clinical studies. (Online only)

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Aged population is increasing in Japan. It is expected that people over 65 years of age will be more than 27 % of total Japanese in 2018. To activate the aged Japanese society, it is required to solve several problems of medical care, social service, employment and nursing care for aged. Young and healthy skin is considered to contribute to making healthy life span longer. Anti-aging medicine is now expected to keep Japanese population healthy till age over 75 years or more.
Skin anti-aging medicine determines the real skin aging of the patients by evaluating a number of pigmented spots, wrinkle length, dryness and elasticity of the skin. Based on the results obtained, patients are advised to treat aged skin in order to recover and keep younger skin.
In this lecture, the clinical, histopathological and molecular difference of aged skin and photo-aged skin is discussed, and the mechanisms of photo-aging and well explained, focusing on the damages of DNA caused by solar ultraviolet radiation.
Finally, protection of the skin against harmful adverse effects of solar radiation and treatment of photo-aged skin are summarized, including topical use and oral intake of antioxidants from small molecules to foods. Experimental and clinical evaluation of CoQ10 is introduced as one of the antioxidants available at present for skin anti-aging. (Online only)

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