Palatal mucosal wound healing in type 2 diabetes model rats after administration of an antibacterial drug
2019 年 53 巻 1 号 p. 15-23
詳細
2019 年 53 巻 1 号 p. 15-23
We investigated the effect of antibiotic administration on spontaneous healing in Goto‐Kakizaki (GK) rats with type 2 diabetes and an experimentally created defect in the palatal mucosa, comparing a control group of 18 male 8‐week‐old Wistar rats and a diabetes mellitus (DM) group of 18 male 8‐week‐old GK rats. In both groups, a cylindrical defect 1.5 mm in diameter was created in the maxillary right first molar region of the palatal mucosa using a biopsy punch to remove all the soft tissue, including the periosteum. Immediately after this surgery, an antibiotic was administered intraperitoneally. Three animals per group were sacrificed for histological testing at healing periods of 1, 3, 5, 7, 14 and 28 days after the surgery. It took longer for the wound to be covered with skin in the DM group than in the control group, and the appearance of granulation tissue and collagen fibers in the lamina propria was delayed. No sequestrum formation occurred in either group. The results of our comparative histological observations showed that spontaneous healing was delayed in GK rats compared with the controls. Our results suggest that if an antibiotic is administered, sequestrum formation may not occur. (J Osaka Dent Univ 2019; 53: 15‐23)
