四塩化炭素および四塩化エタンの急性毒性に関する実験的研究 : クロル炭化水素の肝障害性 第3報

抄録

Carbon tetrachloride and 1, 1, 2, 2-tetrachloroethane have a specific hepatotoxicity and belong to the most toxic agents among chlorinated hydrocarbons. The threshold limit value (TLV) of carbon tetrachloride by ACGIH is 10 ppm, and that of 1, 1, 2, 2-tetrachloroethane is 5 ppm. Therefore, it has been evaluated that the toxicity of carbon tetrachloride is lower than that of 1, 1, 2, 2-tetrachloroethane in the field of industrial hygiene. In order to examine the validity of this evaluation, the authors made Cb female mice weighing 20-23 g inhale the above vapors at 800 ppm for 3 hours separately, and attempted to compare the acute toxicity of carbon tetrachloride with that of 1, 1, 2, 2-tetrachloroethane, observing the course of the changes of lipid contents in the liver and plasma and the damage of liver microsomes after the exposure. The results obtained are summarized as follows: 1. The changes of hepatic triglyceride and phospholipid levels by the exposure to carbon tetrachloride were almost similer to those of 1, 1, 2, 2-tetrachloroethane. 2. The decreasing rate of plasma triglyceride and phospholipid contents by the exposure to carbon tetrachloride was significantly higher than those of 1, 1, 2, 2-tetrachloroethane. 3. The damage of liver microsomes was recognized in the exposures to both carbon tetrachloride and 1, 1, 2, 2-tetrachloroethane. As whole, it is concluded that the hepatotoxicity of carbon tetrachloride is almost the same as that of 1, 1, 2, 2-tetrachloroethane, or the former is a little higher than the latter.