抄録
For the purpose of clarifying the significance of Ca-EDTA as an accelerator of heavy-metal excretion, the interactions between albumin and heavy-metal ions and the effect of Ca-EDTA upon the combination of the metal with albumin were studied under various conditions by polarography. EDTA and Ca-EDTA were found to have the ability to combine with Cd, Pb, and Mn stoichiometrically at pH 7.0, and the complexes were stable. Cadmium combined with bovine serum albumin at the imidazol group, but this combination was inhibited by Tris (Hydroxymethyl) aminomethane. Combination of plumbus ions with albumin was completely inhibited by tartaric ions. EDTA and Ca-EDTA reacted also with the cadmium or lead combined with bovine serum albumin.
