抄録
This study was taken up for the purpose of clearing up the state of the central nervous system affected with lead. I Methods Nine chronically lead-poisoned patients of the age ranging from 18 to 30 years and seven normal clerical employees of the age ranging from 23 to 29 years were chosen at lead smelting works and the examinations were performed as follows: (1) Blood specific gravity, (2) Hemoglobin, (3) Microhematocrit, (4) Basophillic stippled cells, (5) Lead in the whole blood, (6) 24 hours' excretion of urine, (7) Coproporphyrin, (8) Lead in the urine (9) Bluish line along the gums, (10) Subjective symptoms, and (11) EEG and their frequency analysis. II Results 1. The results of the examinations which were statistically significant between the lead poisoned group and the control group are as follows: Microhematocrit, hemoglobin, basophillic stippled cells, lead in the whole blood and in the urine, coproporphyrin, and bluish line along the gums. 2. As to the results of EEG and their frequency analysis of the lead poisoned group, increases of 4∼6 c/s and decreases of 8∼12 c/s and 12∼16 s/c were recognised. The amplitude of EEG of the lead poisoned group was lower than that of the control group. 3. As regards the relation between these examinations and the distribution of EEG frequencies; 1) Increases of 4∼6 c/s and decreases of 12∼16 c/s in the Ht 39.0∼43.3% group were recognised in comparison with the Ht 43.7∼47.4% group. 2) Increases of 4∼6 c/s and decreases of 12∼16 c/s and 16∼20 c/s were recognised in the group of which the lead concentration in the whole blood showed the poisoning level. 3) Increases of 4∼6 c/s and decreases of 12∼16 c/s in the coproporphyrin positive group were recognised. 4) Increases of 4∼6 c/s and decreases of 8∼12 c/s, 12∼16 c/s and 16∼20 c/s were recognised in the group of which the lead concentration in the unine showed the poisoning level. These changes of EEG were statistically significant, and from the relation between those results of examinations and the distribution of EEG frequencies, chronic diffuse changes of the central nervous system in the chronically lead-poisoned group have been briefly discussed.
