骨髄異形成症候群における骨髄細胞周期に関する研究
1994 年 106 巻 7-8 号 p. 861-874
詳細
1994 年 106 巻 7-8 号 p. 861-874
Bone marrow cell cycle analysis was performed on 23 patients with myelodysplastic syndrome (MDS) [12 with refractory anemia (RA), two with RA with ringed sideroblasts (RARS), three with RA with excess blasts (RAEB), six with RAEB in transformation (RAEBt)], and 14 normal volunteers. Cells were stained with propidium iodide and analyzed by flowcytometry.
Patients with RA and RARS (low-risk MDS) showed higher rates of S-phase (21.2±4.9%) and patients with RAEB and RAEBt (high-risk MDS) showed lower rates of S-phase (9.9±5.9%) compared with normal controls (15.2±3.1%). Although the rate of S-phase decreased with disease progression, it was normalized with complete remission. An intermediate correlation (r=0.64, p<0.01) existed between the rate of S-phase and the percentage of erythroblasts in MDS.
The rate of S-phase clearly reflects the severity of MDS. The high rate of S-phase in low-risk MDS was considered to be due to erythroid hyperplasia with ineffective hematopoiesis.
