Prevention of Aberrant Crypt Foci Formation by Dietary Maize and Yeast Cerebrosides in 1,2-Dimethylhydrazine-treated Mice

Kazuhiko AIDA; Mikio KINOSHITA; Mikio TANJI; Tatsuya SUGAWARA; Masahiko TAMURA; Jisaburo ONO; Norimichi UENO; Masao OHNISHI

doi:10.5650/jos.54.45

Biochemistry and Biotechnology

Prevention of Aberrant Crypt Foci Formation by Dietary Maize and Yeast Cerebrosides in 1,2-Dimethylhydrazine-treated Mice

Kazuhiko AIDA, Mikio KINOSHITA, Mikio TANJI, Tatsuya SUGAWARA, Masahiko TAMURA, Jisaburo ONO, Norimichi UENO, Masao OHNISHI

Author information

Kazuhiko AIDA
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
The United Graduate School of Agricultural Sciences, Iwate University
Central Laboratory, Nippon Flour Mills Co., Ltd.
Mikio KINOSHITA
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
The United Graduate School of Agricultural Sciences, Iwate University
Mikio TANJI
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
The United Graduate School of Agricultural Sciences, Iwate University
Tatsuya SUGAWARA
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
Masahiko TAMURA
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
The United Graduate School of Agricultural Sciences, Iwate University
Nippon Beet Sugar Mfg., Co., Ltd.
Jisaburo ONO
Central Laboratory, Nippon Flour Mills Co., Ltd.
Norimichi UENO
Central Laboratory, Nippon Flour Mills Co., Ltd.
Masao OHNISHI
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine
The United Graduate School of Agricultural Sciences, Iwate University

Keywords: cerebroside, sphingolipid, sphingoid base, maize, yeast, 1,2-dimethylhydrazine, aberrant crypt foci, colon carcinoma

JOURNAL FREE ACCESS

2005 Volume 54 Issue 1 Pages 45-49

DOI https://doi.org/10.5650/jos.54.45

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Abstract

For clarification of physiological effects of dietary maize and yeast sphingolipids on colon cancer in vivo, we investigated the effects of dietary maize and yeast cerebrosides on 1,2-dimethylhydrazine (DMH) -induced aberrant crypt foci (ACF) formation in mouse large intestine. After 10 weeks of maize and yeast cerebroside feeding and DMH administration, DMH-induced ACF formation was significantly suppressed in all large intestines of these mice. When lipids in the feces of mice fed maize and yeast cerebrosides were analyzed, maize and yeast cerebrosides decomposed by intestinal enzyme and/or microflora were observed. The present study demonstrated that DMH-induced ACF formation could be inhibited in mouse large intestine by maize and yeast cerebrosides. Daily ingestion of these compounds may serve to suppress colon carcinoma in humans.

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