Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
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In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer’s Disease
Monica Rosa LoizzoFederica MenichiniRosa TundisMarco BonesiFilomena ConfortiFarsad NadjafiGiancarlo Antonio StattiNatale Giuseppe FregaFrancesco Menichini
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2009 Volume 58 Issue 8 Pages 443-446


In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and α-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC50 2.26 μL/mL. Interesting cholinesterase inhibitory activity was also found with IC50 values of 0.32 and 0.29 μL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC50 value of 165 μg/mL. The absence of cytotoxicity at 1000 μg/mL was evaluated by MTT assay in 142BR cells.

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© 2009 by Japan Oil Chemists' Society
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