Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
General Subjects
In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer’s Disease
Monica Rosa LoizzoFederica MenichiniRosa TundisMarco BonesiFilomena ConfortiFarsad NadjafiGiancarlo Antonio StattiNatale Giuseppe FregaFrancesco Menichini
Author information
JOURNALS FREE ACCESS

2009 Volume 58 Issue 8 Pages 443-446

Details
Abstract

In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and α-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC50 2.26 μL/mL. Interesting cholinesterase inhibitory activity was also found with IC50 values of 0.32 and 0.29 μL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC50 value of 165 μg/mL. The absence of cytotoxicity at 1000 μg/mL was evaluated by MTT assay in 142BR cells.

Information related to the author
© 2009 by Japan Oil Chemists' Society
Previous article
feedback
Top