In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer’s Disease

Monica Rosa Loizzo; Federica Menichini; Rosa Tundis; Marco Bonesi; Filomena Conforti; Farsad Nadjafi; Giancarlo Antonio Statti; Natale Giuseppe Frega; Francesco Menichini

doi:10.5650/jos.58.443

General Subjects

In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer’s Disease

Monica Rosa Loizzo, Federica Menichini, Rosa Tundis, Marco Bonesi, Filomena Conforti, Farsad Nadjafi, Giancarlo Antonio Statti, Natale Giuseppe Frega, Francesco Menichini

Author information

Monica Rosa Loizzo
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
Federica Menichini
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
Rosa Tundis
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
Marco Bonesi
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
Filomena Conforti
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
Farsad Nadjafi
Medicinal Plants and Drugs Research Institute, Shahid Beheshti University
Giancarlo Antonio Statti
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
Natale Giuseppe Frega
Department of Food Science, Politecnica delle Marche Universit
Francesco Menichini
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria

Keywords: Salvia leriifolia, Essential oil, GC-MS, Cholinesterase inhibition, NO production inhibition

JOURNAL FREE ACCESS

2009 Volume 58 Issue 8 Pages 443-446

DOI https://doi.org/10.5650/jos.58.443

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Abstract

In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and α-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC₅₀ 2.26 μL/mL. Interesting cholinesterase inhibitory activity was also found with IC₅₀ values of 0.32 and 0.29 μL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC₅₀ value of 165 μg/mL. The absence of cytotoxicity at 1000 μg/mL was evaluated by MTT assay in 142BR cells.

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