Journal of Oleo Science
Online ISSN : 1347-3352
Print ISSN : 1345-8957
ISSN-L : 1345-8957
Oils and Fats
Comparative Analysis of the Gut Microbiota in Mice under Lard or Vegetable Blend Oil Diet
Bo QiaoXiaoya LiYi WuTan GuoZhoujin Tan
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2022 Volume 71 Issue 11 Pages 1613-1624


Diet is the most direct and rapid contributor to the gut microbiome. Oils and fats are important nutrients in the human body. The effects of lard or vegetable blend oil on gut microbiota were investigated. Kunming mice were given lard or vegetable blend oil for six weeks. Changes in microbiota composition and abundance in lard or vegetable blend oil diets were analyzed by 16S rRNA gene amplicon sequencing. Our study shows that the gut microbiota of mice changed significantly after ingestion of lard or vegetable blend oil. Lard may synergize with Coriobacteriaceae_UCG-002. Vegetable blend oil has synergistic effects with Akkermansia, Roseburia, and Enteractinococcus. Coriobacteriaceae_UCG-002 showed a significant negative correlation with Glycolysis/Gluconeogenesis. Roseburia was most strongly associated with Starch and sucrose metabolism. According to bacterial function prediction and correlation analysis, long-term consumption of lard or vegetable oil may affect glycolipid metabolism, but lard has a greater impact on human health and consequently host health.

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© 2022 by Japan Oil Chemists' Society

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